PPAR-α Modulators as Current and Potential Cancer Treatments

Cancer is one of the leading causes mortality worldwide. PPAR modulators may hold great potential for management cancer patients. Indeed, PPARs are critical sensors and regulators lipid, they able to promote eNOS activation, regulate immunity inflammation response, affect proliferation differentiation cells. Cancer, a name given group diseases, characterized by multiple distinctive biological behaviors, including angiogenesis, abnormal cell proliferation, aerobic glycolysis, inflammation, etc. In last decade, emerging evidence has shown that PPAR-α, nuclear hormone receptor, can modulate carcinogenesis via exerting effects on or several characteristic pathological behaviors cancer. Therefore, multi-functional have substantial promise in various types therapies. This review aims consolidate functions as well discuss current applications PPAR-α agonists antagonists tackling